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Today, drugs are known with proven efficacy for the prevention of major cardiovascular and cerebrovascular events: antiplatelets, ACE inhibitors, and lipid-lowering drugs (mainly statins, which additionally have a proven benefit for walking distance) [48]
Joyce, N
doi:10.1007/s10815-019-01461-6
The lower limit of the 95% CI above unity indicated that the systemic exposure to dersimelagon in plasma, based on AUC 0- and C max values, appeared to increase in a slightly more than dose-proportional manner over the 1- to 600-mg single dose range (eTable 3)
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