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doi: 10.1007/s00726-016-2254-8 70 YangW

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The TGF-/Smads pathway negatively regulates the paired-box homeotic gene 3 (PAX3), which works synergistically with the SRY-Box Transcription Factor 10 (SOX10) to upregulate MITF, dependent on a cAMP-response element (CRE) 46 , 47

The books (vertebrae) may become unstable and start to slide out of place under pressure
