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574,575 Anti-inflammatory effects were also demonstrated for 13-HOTrE and the corresponding hydroperoxide 13-HpOTrE, with both compounds decreasing pro-inflammatory cytokine/enzyme levels while simultaneously increasing anti-inflammatory cytokines in LPS-challenged RAW 264.7 and mouse peritoneal macrophages

Lipid mediators generated from EPA (E series resolvins) and DHA (D series resolvins, protectins, maresins) (62) have anti-inflammatory properties contrary to n-6 derivatives (59)

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References: Molecular evolution of the lysine biosynthetic pathways