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The 12 mg group achieved 24.2% weight loss at 48 weeks in Phase 2, and 28.7% at 68 weeks in the Phase 3 TRIUMPH-4 trial

While this was insufficient to rescue selenium in PS mutant induced neurons, which are severely deficient in selenium, it appeared sufficient to normalize selenium in non-PS mutant sAD cells

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Cells culture (200 l) were then harvested on glass microfiber GF/CTM filters (Whatman, United Kingdom) and washed with 3 ml 7% trichloroacetic acid followed by 3 ml absolute ethanol