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As a secondary effect, it inhibits thalamocortical glutamatergic neurons by inducing cell activation and stimulating the adenylyl cyclase pathway

Perinatal developmental programming gives offspring the ability to make inferences about the postnatal energetic environment through maternal cues (384), and several studies indicate that maternal HFD during gestation leads to obesity in offspring (222, 420, 478)

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High expression of forkhead box D1 (FOXD1), which is closely related to a poor prognosis for patients with pancreatic cancer, promotes the upregulation of GLUT1 expression and glucose uptake in cancer cells by activating the transcription of solute carrier family 2 member 1 (SLC2A1) and the lncRNA HOXA11-AS, which aggravate the malignant behavior of cancer cells [27]
