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International journal of surgery

Sacchi S, Kantarjian HM, O'Brien S, Beran M, Koller C, Pierce S, Kornblau S, Estey E, Keating MJ, Talpaz M

The H 2 O 2 concentration drives the redox balance in the cell from GSH toward GSSG (see Figure 1) and the increased concentrations of H 2 O 2 and GSSG can modulate many enzymes in one-carbon metabolism (see Section E)

Activation of protein C by the thrombin-thrombomodulin complex: Cooperative roles of Arg-35 of thrombin and Arg-67 of protein C

This relatively high concentration helps protect the stability of the red blood cell membrane and prevents hemoglobin from being oxidized to methemoglobin, thereby preserving its oxygen-carrying capacity