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Notably, lung cancer cells with KEAP1 mutations exhibit Nrf2 activation and sensitivity to GLS inhibition [37], suggesting that the use of GLS inhibitors has a good prospect in the treatment of lung cancer patients with KEAP1 mutations, and may provide a new therapeutic strategy for the treatment of patients with high SLC7A11 expression in their lung tumors

Int Arch Allergy Immunol 162(1):2538

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Amsterdam, The Netherlands: Elsevier Publication

In brief, PDLSCs were seeded in 6-well plates (Invitrogen) at a density of 2 10 5 cells/well and cultured until 6070% confluence