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Schoenthaler SJ, Bier ID: The effect of vitamin-mineral supplementation on the intelligence of American schoolchildren: a randomized, double-blind placebo-controlled trial

Elevated B12 levels can be a marker for liver diseases, kidney diseases, and blood diseases, including different types of leukemia (chronic myelogenous leukemia and promyelocytic leukemia)

Results: Berberine reduced renal injury in STZ-induced DN rat model, as evidenced by the decrease in fasting blood glucose, ratio of kidney weight to body weight, 24-h urinary protein, serum creatinine, and blood urine nitrogen

Meanwhile, even though your Folic Acid status is great and red blood cells appear normal, not having enough B12 will cause homocysteine to build up, leading to neurological damage and changes in DNA function without you realizing it until symptoms set in

5 This can have significantly detrimental effects on the nervous system, cell division, and other methylation processes