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Additionally, other angiogenic growth factors, including stromal-derived factor 1, stem cell factor, and angiopoietin family members, are also regulated by HIFs and participate in tumor vascularization 115117

For example, structural alterations and eventual damage were brought about by the interaction of SNPs with bacterial membrane constituents, which ultimately resulted in bacterial cell death

In areas of vulnerable plaque where apoptotic cells are present, macrophages can attenuate collagen production in VSMCs without inducing cell death by secreting lower levels of TGF-, a key stimulator of collagen synthesis in SMCs

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Hypoxia-driven intratumor heterogeneity and immune evasion