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For example, cultured astrocytes subjected to oxygen and glucose deprivation showed a decrease in mitochondrial membrane potential, possibly caused by the mitochondrial permeability transition pore (mtPTP) opening, which leads to a loss of intramitochondrial contents, mitochondrial respiration and ATP production [48]

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de Vries F et al.: Opioids and Their Endocrine Effects: A Systematic Review and Metaanalysis

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Multi-peptide protocols require more attention than single compounds