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Tirzepatide is a once-weekly, dual-incretin peptide it activates both the GIP and the GLP-1 receptor from a single molecule and in published obesity trials it has produced some of the largest average weight reductions of any incretin agent studied to date

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Learned avoidance requires VTA KOR-mediated reductions in dopamine

Clinical data further reveal an inverse correlation between heart rate variability (HRV, an indicator of vagal activity) and the severity of BBB damage, suggesting that vagal activity contributes to BBB regulation through cerebrovascular dilation and hemodynamic control (159)

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