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MNAM, a natural inhibitor of NNMT, is generated through the enzymatic reaction catalyzed by NNMT (Swaminathan et al., 2017), the X-ray crystal structure of a ternary complex of NNMT bound with MNAM was elucidated, revealing that MNAM binds to the active site of NNMT, thereby impeding NAM binding and suppressing NNMTs enzymatic activity

However, the rate of additional fat loss likely diminishes as total body fat decreases

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4.2 Small molecule inhibitors targeting NNMT In addition to RNAi drugs, the development of small molecule inhibitors targeting NNMT represents a current research focus for the treatment of MetS-related diseases

Vitamin B12 can be converted to coenzyme B12 in tissues