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When the cellular demand for NAD+ to sustain oxidation exceeds the rate of ATP turnover, particularly in cells exhibiting active aerobic glycolysis, NAD+ regeneration becomes a limiting factor under conditions of compromised mitochondrial respiration

[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine