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Apo M as a chaperone of sphingosine-1-phosphate (S1P) contributes to the formation of Apo M/S1P complex in HDL, which interacts with S1P receptors (S1PR) to promote vascular barrier function and exert antiinflammatory functions 90,91
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A clear understanding of the relative risk is essential, and the major established coronary risk factors in humans remain well documented [70]
