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CYP27A1 effectively catalyzes the first rate-limiting step in the alternative pathway, while 7-hydroxysteroid 7-hydroxylase (CYP7B1) participates in subsequent 7-hydroxylation, responsible for the majority of CDCA synthesis (Rao et al., 2008)
doi:10.1016/j.arthro.2024.09.005
However, much of the research on BPC-157 has been conducted in animals, and key questions about safety, effectiveness, dosing, and long-term outcomes remain unanswered
