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Nature 496 (7443), 101105

The first report of colchicine for treating OSF was documented in 2013 (Krishnamoorthy and Khan, 2013)

Our results are consistent with the study by Shin et al

IGF-1 LR3: mechanism and evidence base IGF-1 LR3 (insulin-like growth factor 1 long arginine 3) is an 83-amino-acid synthetic analogue of human IGF-1 in which glutamic acid at position 3 is replaced with arginine and an additional 13-amino-acid extension is appended to the N-terminus

Oxidative Defense Reactive oxygen species increase with age and cause sperm motility and DNA damage, increasing fragmentation
