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doi: 10.1002/mnfr.200700195
doi: 10.1038/s41593-021-00999-y

Finding evidence of diffuse vascular insufficiency on the brain scan of an older patient is so common that it is often read as normal for age. Consequently, healthcare practitioners often tell such patients that their scan was normal. However, when this finding occurs in a patient who is having symptoms that could be associated with vascular insufficiency, the situation and the brain scan should be re-evaluated

A foundational 2005 study by Guideri et al

Incidence and clinical relevance of the interactions and side effects of Hypericum preparations
