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TAS, RKC, IK and MH drafted the manuscript

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Inpatients (i.e., more severely depressed patients) may be given up to but not in excess of 600 mg/day in divided doses Once an adequate response has been achieved, dosage may be gradually reduced, with subsequent adjustment depending on therapeutic response

Sibutramine, a popular antiobesity drug used worldwide since 1997, was withdrawn from the European and US markets in 2010 because of safety concerns [27,28]

In fact, it is also involved in the metabolism of amino acids and nucleic acids like folic acid, and it assists in synthesizing DNA, RNA, and fatty acids