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For Doxorubicin, this led to a very high exposure which exceeded the PoD for all readouts for all days, corresponding to BERs between 0.00050.2
113, 114 Evaluation of the tumor vasculature after antibody-mediated PS blockade revealed accumulation of macrophages around tumor blood vessels and subsequent vascular destruction akin to antibody-dependent cellular cytotoxicity 114 (Figure 7)

Despite these findings, the mechanisms underlying the increased levels of cell death and its contribution to the immunological and clinical phenotype of DADA2 remained elusive

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