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Clinical trial data presented at obesity medicine conferences, 2024

Roles of Wnt8a during formation and patterning of the mouse inner ear

Cisplatin exacerbates hair cell damage through a dual mechanism: on the one hand, it activates nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy, which prompts ferritin to release free Fe 2+ , generating a large amount of reactive oxygen species (ROS) via the Fenton reaction and inducing a lipid peroxidation chain reaction (Dai et al., 2024)