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Kareem R, Botleroo RA, Bhandari R, et al

Tricyclic antidepressants (TCAs) Amitriptyline and nortriptyline: Effective in managing PDPN by inhibiting monoamine reuptake and blocking sodium channels
The first is Intrinsic solubility which is the solubility measured after equilibrium between the dissolved and solid state at a pH where the compound is neutral (DrugBank 2023)

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