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While L-carnitine was historically used widely to promote the shuttling of long-chain fatty acids and other organic acids into the mitochondria while removing toxic metabolites, it is no longer routinely used due to the association of its chronic use in the general population with atherosclerosis[58,59]

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For example, Clostridium difficile induces Treg cells, and Segmented Filamentous Bacteria (SFB) and Citrobacter induces the development of functionally distinct Th17 cell populations in the gut, respectively (Ivanov et al., 2009