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and pre-existing subpopulations, cells in which intrinsic pathway activation promotes proliferation and the presence of cancer stem cells, serve as a defense barrier against the toxicity of anticancer drugs, contributing to intrinsic drug resistance (41, 42)

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[DOI] [PubMed] [Google Scholar] Hensley CT, Wasti AT, DeBerardinis RJ

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[DOI] [PMC free article] [PubMed] [Google Scholar] Widiputri, D

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