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Similarly, the D R 8 A(2535) also had CD spectra consistent with random coil structure, which lacked strong negative ellipticity at 200 nm due to the presence of eight Dform arginines in the peptide (Appendix Fig S1C)

Since all the fragments crystallized in subpocket C contained HEPE moiety with an additional polar substituent, it was tempting to think that a similar polar moiety should be placed in subpocket C

As synaptic plasticity is impaired, or otherwise maladaptive, in various neuropsychiatric disorders [182,183] including depression [184], its facilitation by BDNF represents an important potential therapeutic mechanism

10.1002/eji.200737995 13 BloomK.van den BergF.ArbuthnotP

Mohamed S, Pemmaraju N, Sasaki K, Borthakur G , Abuasba T, Khan M, Hwang H, Wang X, Verstovsek S, Busaidy N