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Unlike L-arginine, oral ingestion of L-citrulline is not catabolized by arginase in the intestine, and the enzymatic activity of argininosuccinate synthetase (the enzyme that catabolizes L-citrulline) is relatively low in intestinal epithelial cells [45]

2.2 PICOS framework To ensure a systematic approach to our review, we employed the PICOS framework as illustrated in Figure 2

After the addition of TGF1 to the low-glucose medium, -SMA expression in PSCs increased significantly

Wishing you all great health, Warm regards, Rajsree Nambudripad, MD

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