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Headaches and Fatigue: Some users report mild headaches or temporary fatigue during initial supplementation, likely related to detoxification processes and cellular adjustments to enhanced antioxidant capacity

Still, these effects are largely theoretical for humans based mostly on short-term lab data, not clinical human trials

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However, in the human clinical setting an NMP perfusate could never be composed of whole blood (171)

Bezafibrate inhibits HMG-CoA reductase activity in incubated blood mononuclear cells from normal subjects and patients with heterozygous familial hypercholesterolaemia