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25 In two randomized placebo-controlled trials, totaling 1257 patients with diabetic neuropathy, Sima and colleagues failed to find any significant electrophysiological change in patients treated with 500 or 1,000 mg ALC, although a significant improvement in the vibration perception threshold was reported

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doi: 10.1093/ajcn/38.4.532 23

The pathophysiological mechanism of epilepsy caused by propionic acidemia is similar to that of methylmalonic acidemia