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Research suggests these peptides may influence multiple overlapping biological pathways

For example, erythrocytes and neurons strongly rely on G6PD whereas adipocytes and liver cells are more reliant on IDH1 and ME1 [14,74,75]

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In certain embodiments, any controlled release otic formulation described herein increases the exposure of a therapeutic agent and increases the length of time that the concentration of a therapeutic agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80% or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition

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