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We are currently completing studies to clarify the temporal expression levels of astrocytic EAAT1 and EAAT2 and neuronal EAAT3 transporters in the spinal cord and brains of both male and female rodents subjected to SNI

The analysis integrates findings from preclinical investigations, limited clinical data, and regulatory perspectives

50 Reyes AJ, Leary WP, Locket CJ, et al

Onset of Action and Duration: Injectable delivery often provides faster plasma peaks and more stable long-term concentrations

According to the applicant, the Total Ankle Talar Replacement has not yet received Breakthrough Device designation from FDA, but the applicant is seeking the designation for use with a premarket authorized total ankle arthroplasty system as part of an ankle arthroplasty system to manage talar dysfunction that may be associated with the following indications: failed ankle arthroplasties, talar trauma, tumors or lesions, ankle arthritis/degenerative joint disease, ankle arthrodesis or malunion, talar osteomyelitis/infection or ankle/foot deformities