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There is evidence that these impurities can seriously affect patients

, Li, M

Common side effects may include: Injection site reactions (redness, swelling, pain) Headaches or dizziness Water retention or bloating Fatigue or sleep disturbances Hormonal imbalances (if affecting endocrine function) Increased hunger (especially with growth hormone-related peptides) Rarely, misuse or unregulated peptides may lead to more serious effects, such as insulin resistance or elevated IGF-1 levels

These functions are crucial in preventing acid backflow, which is the primary concern for patients with GERD

In case of high-risk patients or new-onset subclinical neurographic changes, starting slowly or lowering the speed and the dose of infusion respectively, might help avoiding the risk of progression of the PN and even improve the PN (Rispoli et al