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Description
NNMT inhibition may actually improve the adipocytes capacity to oxidize fat by restoring the NAD+-dependent sirtuin activity and mitochondrial function that fatty acid oxidation requires

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Its worth noting that excess B12 blood serum levels can come from taking the common, cheap form of B12, cyanocobalamin, which for many does not convert into an active form the body needs to absorb and use - therefore it does not get transported for cellular use (and is instead floating around in the bloodstream without positive effect)
PMID: 20445536
