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The anxiolytic mechanism of Selank involves modulation of GABAergic neurotransmission through allosteric effects on GABA-A receptor sensitivity, distinct from the direct binding site used by benzodiazepines

Research demonstrated that, after 24 h for intramuscular administration and 1.5 h for nasal application, Epitalon enhanced IL-2 mRNA synthesis rates in the lateral hypothalamus area, anterior hypothalamic fields, dorsomedial, ventromedial, and paraventricular hypothalamic nuclei [96]

Merav Jacobson Bensky, Irit Ayalon-Dangur, Roi Ayalon-Dangur, Eviatar Naamany, Anat Gafter-Gvili, Gideon Koren, Shachaf Shiber (2) Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route