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Many of these agents, including peptide-based and hydrophobic small molecules, exhibit poor CNS bioavailability, necessitating advanced delivery systems such as nanoparticles, convection-enhanced delivery, or BBB permeabilizing strategies [113, 153]
Bolger AM, Lohse M, Usadel B
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Arterioscler Thromb Vasc Biol 23: 411417, 2003 [DOI] [PubMed] [Google Scholar] 56.Levy HR, Christoff M
Separation was achieved using a gradient of Solvent B (10 mM TEABC, pH 8.0, 90% ACN) and Solvent A (10 mM TEABC, pH 8.0) at the flow rate of 250 L/min
