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Description
As a base excision repair protein, PARP overactivation has been linked to mitochondrial dysfunction in xeroderma pigmentosum group A, as well as ataxia telangiectasia and Cockayne syndrome with similar pathogenesis involving nuclearmitochondrial communication
Nat Commun 7 , 11030 (2016)

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Loss of Pgc-1alpha expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation
