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PTL conceived the study, participated in its design, and coordination, and helped to draft the manuscript

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The osmolytes in the astrocytes provide cellular defense against edema and can be rapidly accumulated or depleted, according to osmotic sensors

doi: 10.1038/s41586-019-1443-5 Summary Keywords anti-NMDAR encephalitis, gut microbial compositional shift, metabolites, blood-brain barrier, therapeutic potential Citation Shen C, Xie Y, Xie Y, Wang L, Han A, Zhou X, Zhang S, Fu X and Xie N (2025) The gut-brain axis: potential reshaping the future of anti-NMDAR encephalitis treatment