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Once embryos reach the blastocyst stage of development, they hatch from the zona pellucida and implant in the uterine endometrium

The degree of heterogeneity across the results of different studies was quantitatively assessed by the I 2 statistic, with I 2 50% indicating substantial heterogeneity [11]

8.3 Acquired hypothyroidism and hypothalamic pituitary adrenal axis The HPA axis is a vital neuroendocrine circuit responsible for regulating a variety of physiological processes and responses to stress (91)

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