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It has been investigated for its potential involvement in regulating sleep patterns, neuroendocrine function, and stress-related hormone signaling

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Although these treatments show promise, definitive evidence of their efficacy has yet to be established, and the potential side effects require careful consideration to ensure their safety and effectiveness in clinical use

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A review of forty-nine observational studies published in the May 2011 issue of the Cochrane Database of Systematic Reviews concluded that higher selenium exposure reduces overall cancer incidence by about 34 percent in men and 10 percent in women, but notes these studies had several limitations, including data quality, bias, and large differences among different studies