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However, in chronic inflammatory bowel disease, dysregulated AhR signaling, driven by gut microbiota imbalances, exacerbates oxidative stress, lipid peroxidation and iron deficiency in intestinal epithelial lymphocytes, and this can potentially be mitigated by specific AhR inhibitors (26)

Most people can consume dietary glutamate in large amounts or their body can metabolize glutamate efficiently

During hematopoiesis, HSCs primarily utilize glycolysis and OXPHOS to a lesser extent when they are in a dormant state

Cellular senescence and metabolic reprogramming: unraveling the intricate crosstalk in the immunosuppressive tumor microenvironment