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During oxidative stress, modifications in cysteine residues on Keap1 release Nrf2, allowing it to translocate into the nucleus, bind to AREs in target genes, and initiate transcription of essential antioxidant genes 67
10.1016/j.cmet.2007.10.002 38
Song, W.L., Lawson, J.A., Reilly, D., Rokach, J., Chang, C.T., Giasson, B., FitzGerald, G.A
Association of mitochondrial dysfunction and fatigue: a review of the literature
Additionally, GSK-J4, a dual inhibitor of histone lysine demethylase 6A/6B that prevents H3K27 demethylation, can suppress palmitic acid (PA)-induced hypersensitivity to ferroptosis by inhibiting ACSL4 expression and lipid peroxidation in cardiomyocytes[204]
