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The transcription factor IRF4 is essential for TCR affinitymediated metabolic programming and clonal expansion of T cells

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Zinc deficiencies, which are very common, lead to increased copper levels, as well as low ceruloplasmin, all of which translates into elevated 'free copper'

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5l) but neither compound significantly altered the colocalization of TLR7 or TLR9 with Rab5 + early endosomes or Rab7 + late endosomes (Supplementary Fig