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ROS can inhibit SERCA function by both interfering with the ATP binding site and by uncoupling calcium uptake from ATP hydrolysis (356, 414)
The proportion of EOPD among whole PD patients ranged from 8.81% to as 4.42 % during the observation period, and this trended to decreased
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Future research should focus on integrating methylation-based classifiers into clinical practice, further validating their predictive utility, and exploring novel epigenetic targets for therapeutic intervention
