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Binding (Non-Neutralizing) Autoantibodies Mechanism: These antibodies bind to FR at sites other than the folate-binding pocket but still trigger immune-mediated damage

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3 Alternative approaches to targeting ferroptosis In addition to the small molecule ferroptosis inhibitors traditionally used to inhibit ferroptosis that can play a role in ferroptosis-mediated diseases, gene regulatory approaches, cellular therapies, and nano-targeted delivery can also exhibit ferroptosis inhibition by all along the correlates of ferroptosis (Table 2), and there are some differences in treatment efficiency between them (Table 3)

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