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In addition, ACh exerts multiple regulatory effects on the immune system: in most cases, ACh suppresses the cytotoxic function of CD8 + T cells and the inflammatory response of macrophages

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Brautigam CA, Wynn RM, Chuang JL, Chuang DT

In the real world, environmental toxins, your diet, stress, and other lifestyle issues have disabled the checks and balances of this system, encouraging your body to make more of the pro-inflammatory prostaglandins and less of the anti-inflammatory ones

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(3) Endocrine Disruption (Bottom Left): Chronic pain/stress activates the systemic HPA axis (Cortisol ), inhibiting the HPG axis (GnRH, LH/FSH, Testosterone )