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Additionally, oxidatively modified HMGB1, along with ROS and myeloperoxidase (MPO) released by neutrophils, can promote the formation and rupture of atherosclerotic plaques, thereby accelerating the progression of cardiovascular disease [243]

However, Ma et al

Meanwhile, HIF-1 can inhibit chondrocyte catabolism and maintain the dynamic balance of articular cartilage matrix by regulating NF-B signalling and limiting the expression of matrix metalloproteinase (MMP)-13 (58)

Brain tissue is particularly vulnerable to OS and highly susceptible to oxygen radical damage because of its high oxygen consumption and lack of antioxidant enzymes

All experimental data are presented as mean standard deviation