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These models have been successfully applied in recent years (53, 145)

Curcumin, a natural NF-B inhibitor, has been studied in the context of neurodegenerative and metabolic diseases, but its therapeutic value remains inconsistent owing to its poor bioavailability and rapid metabolism

Cell death was assessed using propidium iodide (PI) red fluorescent probe to quantify the proportion of PI-positive cells, as previously reported 53

In CML, a Philadelphia chromosome is formed by the translocation between 9 and 22 chromosomes occurred at the 3' end of ABL gene on the chromosome 9 and at the 5' end of BCR gene on the chromosome 22

It follows that comparing levels of oxidized proteins in tissues obtained from two groups of animals with different rates of protein turnover would lead to spurious conclusions about the magnitude of oxidative damage in tissues from two experimental groups