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Besides cardiovascular disease, TMAO also contributes to renal insufficiency and mortality risk in chronic kidney disease, type II diabetes, insulin resistance, non-alcoholic fatty liver disease and colorectal cancer as well (Tang et al., 2015

In patients with renal dysfunction, refractory hypotension, severe metabolic abnormalities, active seizure, or persistent coma, extracorporeal removal by haemodialysis or haemofiltration may be considered, although there are no controlled trials that demonstrate an improvement in outcome with these measures [8890]

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Comparison of colorimetric, fluorometric, and liquid chromatography-mass spectrometry assays for acetyl-coenzyme A

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