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6.4.2 The role of self-immolative spacers For payloads that diminish efficacy with modest structural alterations, self-immolative spacers (e.g., p-aminobenzyloxycarbonyl or PAB) function as a chemical disappearing act. These spacers are positioned between the cleavage site and the drug

Other Niacinamide Combinations: A serum containing 5% niacinamide, 3% tranexamic acid, and 1% kojic acid demonstrated efficacy for facial dyschromia [213]

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10.1016/j.bbi.2023.09.017 78 NanceE.KambhampatiS

This paradigm is obviously particularly important, as it prevents the rapid release of a large amount of substance into the bloodstream with the detrimental consequences already mentioned, but it is equally important to develop formulations that enable the controlled release of the active ingredient from these deposits as a way to extend the duration of the expected effect