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However, profound GSH depletion converts cell death induced by a variety of agents from apoptosis to necrosis (Hall, 1999), suggesting very high levels of ROS may overwhelm the apoptotic machinery

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Furthermore, GH was found to induce the so-called browning of adipocytes by increasing the amount of beige adipocytes in the white adipose tissue and as a consequence, decreasing the store of excess lipid as white adipocytes, which may function as a protective mechanism against obesity (196)

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