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Polivy J

Recent studies have demonstrated that p53 contributes to iron homeostasis by transcriptionally regulating the expression of solute carrier family 25 member 28 (SLC25A28) and ferredoxin reductase (FDXR) to enhance the susceptibility of cells to ferroptosis [127, 128]

It is consistent with the literature suggesting that CBD's antioxidant activity may involve activating the redox-sensitive nuclear erythroid 2-related factor (Nrf2) 41 which plays a pivotal role in activating the endogenous antioxidant defense system 42

This is attributable to the presence of a highly activated carbon atom in the heptadienone linkage between the two-methoxy phenol rings of bis-keto form of curcumin

Excess catecholamines can induce coronary artery constriction, raise heart rate, and increase myocardial oxygen consumption