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In the case of Alzheimers disease, AD, analysis of post-mortem brain samples from patients found that Grx1 levels were increased relatively to control patients whereas Trx1 levels appeared downregulated

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The thiolated poly (ethylene glycol) folate (SH-PEG 5000 -FA) was obtained by coupling SH-PEG-NH 2 (Mn 5,000) with Folate N-hydroxysuccinimidyl ester via a previously published method [29-31]

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